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Palmitoyl Tripeptide-38

Rating: Best

Benefits: Anti-Aging, Hydration,

Categories: Peptides,

Palmitoyl Tripeptide-38 at a Glance

  • Synthetic peptide that has signaling properties
  • Plumps, hydrates & improves fullness
  • Smooths to help the look of lines and wrinkles
  • Helps support key proteins in skin’s extracellular matrix
  • Effective at very low use levels as part of a blend

Palmitoyl Tripeptide-38 Description

Palmitoyl tripeptide-38 is what’s known as a matrikine-mimetic peptide, a type of lab-engineered (synthetic) signal peptide that mimics the role of matrikines in skin. Matrikines are protein fragments that play a “lock-and-key” role in stimulating collagens, hyaluronic acid, and other extracellular matrix proteins while also helping with collagen repair. Applied to skin, palmitoyl tripeptide-38 helps support key adhesion and communication proteins in skin, visibly improving firmness, smoothness, and, in the case of use on lips, the look of fullness.

Other studies relating specifically to palmitoyl tripeptide-38 have shown that it helps improve the appearance of multiple signs of aging, including fine lines, wrinkles, uneven skin tone, and dullness. This research also shows that palmitoyl tripeptide-38 is even more effective in this capacity when combined with other skin-beneficial ingredients such as antioxidants and hyaluronic acid.

Speaking of hyaluronic acid, another of palmitoyl tripeptide-38’s benefits is the support of youthful levels of hyaluronic acid in skin and lips, resulting in a plumped, smoothed appearance and better moisture retention.

Use levels of palmitoyl tripeptide-38 in skin and lip care is typically 1% when the peptide is a fractional part of a blend due to it being effective in very low (parts per million) amounts.

Palmitoyl Tripeptide-38 References

UL Prospector, Accessed August 2024

Molecules, July 2021, pages 1–43

Journal of Cosmetic Dermatology, December 2020, pages 3,262–3,269

Clinical, Cosmetic, and Investigational Dermatology, December 2019, pages 533–544

Journal of Drugs in Dermatology, July 2015, pages 699–704

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding usage constraints, permitted concentration levels and availability vary by country and region.
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