Hydroxypalmitoyl Sphinganine

Hydroxypalmitoyl Sphinganine at a Glance

• Ceramide precursor that helps improve skin barrier function
• Boosts hydration by stopping moisture loss from skin’s uppermost layers
• Can improve skin’s firm, plump appearance
• Nudges skin to make more of its own ceramides naturally

Hydroxypalmitoyl Sphinganine Description

Hydroxypalmitoyl sphinganine is a ceramide precursor that helps improve skin barrier function and hydration. It has been proven to be effective for stopping moisture loss from skin’s uppermost layers.

As a ceramide precursor (sometimes referred to as pseudoceramide), hydroxypalmitoyl sphinganine nudges skin’s uppermost layers to make more ceramides naturally. This is significant because ceramide-deficient skin is not able to retain moisture and keep its appearance firm and plump.

In 2020, the Cosmetic Ingredient Review Expert Panel concluded that hydroxypalmitoyl sphinganine is safe in cosmetics in the practices of use and concentration described in their assessment. Their report looked at products containing between 0.0025-0.062% (high concentrations of this ingredient aren’t necessary for efficacy). 

This ingredient may be synthetic or derived from plants or animals.

Hydroxypalmitoyl Sphinganine References