Genistein at a Glance
- Belongs to a set of compounds known as isoflavones, which are sources of phytoestrogens
- Commonly derived from soy
- Has antioxidant and skin-soothing properties
- Has been shown to visibly improve signs of aging that occur or accelerate during menopause
Genistein Description
Genistein is a naturally occurring plant ingredient that belongs to a group of compounds known as isoflavones. Isoflavones are sources of phytoestrogens, also known as plant estrogens, that are not hormones but can connect with receptor sites on skin’s surface, helping it look and feel younger. Genistein is most often derived from soy but can also be produced synthetically (Paula’s Choice Skincare uses the natural variety).
As an isoflavone, genistein is a rich source of antioxidants that have impressive skin-soothing properties. Research shows that genistein has multiple benefits for skin, both when it’s ingested and used topically. Applied to skin, genistein exhibits anti-aging effects, including reducing the visible appearance of wrinkles and helping protect skin from the effects of sun damage.
It penetrates skin better than “sister” isoflavone daidzein, but research has shown that these ingredients work even better when paired in a single formula. This is due to the synergy they share as well as both having an affinity for key receptor sites on skin’s surface.
Emerging studies also show genistein has a special ability to improve signs of aging and dry skin that are common during menopause. It is typically used in amounts of 0.251% for these benefits, although studies have been done looking at concentrations up to 4%.
Genistein References
Phytotherapy Research, March 2020, Volume 34, Issue 3, pages 435-447
Surgical and Cosmetic Dermatology, March 2020
International Journal of Women’s Dermatology, June 2019, pages 85-90
AAPS FarmSciTech, October 2018, Issue 19, Volume 7, pages 3029-3,039
Nutrients, June 2017, Volume 9, Issue 6, page 622
Journal of Photochemistry and Photobiology B: Biology, March 2015, pages 20-27
International Journal of Pharmaceutics, November 2008, pages 36-44
The Journal of Nutrition, November 2003, Volume 133, Issue 11, pages 3811S–3819S
Journal of Investigative Dermatology, May 2003, pages 835-841