Argireline at a Glance
- Also known as acetyl hexapeptide-8 and acetyl hexapeptide-3
- Synthetically derived
- Has water-binding abilities and skin-restoring properties
- Is considered a neurotransmitter-inhibiting peptide
Argireline Description
Argireline is a synthetically derived peptide that is used in a wide range of skin care and makeup products. Also known as acetyl hexapeptide-8 and acetyl hexapeptide-3, it, like all peptides, has water-binding properties and skin-restoring abilities. It is considered a neurotransmitter-inhibiting peptide, meaning it works within skin’s surface layers to interrupt the look of expression lines; however, its efficacy in this regard doesn’t replace in-office wrinkle-smoothing injectable procedures.
Interestingly, research from suppliers has shown this peptide also helps support skin’s collagen and preserve a firmer appearance.
On the other hand, research has shown this peptide can penetrate further into skin if specific formulary steps are followed, including the type of emulsion (a higher water content showed greater penetration). As always, this demonstrates the importance of selecting well-formulated skin care products to add to your routine.
Argireline References
Cosmetic Ingredient Review, April 2021, pages 1-12
Cosmetics, November 2020, Issue 7, Volume 4, page 91
La Clinica Terapeutica, November 2020, pages e539-e548
Cutaneous and Ocular Toxicology, March 2015, pages 46-52
European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
Dermatologic Therapy, September-October 2007, pages 343-349
International Journal of Cosmetic Science, October 2002, pages 303-310