Acetyl Tetrapeptide-2 at a Glance
- Synthetic peptide
- Support skin’s extracellular matrix
- Encourages healthy levels of elastin
- Has skin soothing properties
Acetyl Tetrapeptide-2 Description
Acetyl tetrapeptide-2 is a lab-synthesized peptide created by the acetylation of tetrapeptide-2. Acetylation is the process of adding an acetyl group (molecular compounds that modify proteins and enzymes) to a compound to change its function. Acetyl tetrapeptide-2 is derived from thymopoietin, a polypeptide originating in the thymus gland.
Research finds acetyl tetrapeptide-2 helps support skin’s extracellular matrix and helps improve skin’s elasticity. It does so by encouraging healthy levels of elastin (elastin being one of the chief substances responsible for skin’s youthful “bounce”). The peptide helps reinforce skin’s barrier, making it more resilient to environmental stressors and aging.
Studies have also demonstrated that acetyl tetrapeptide-2 has skin soothing properties.
The supplier-recommended use level is 2–10% with the peptide being suspended in a water and dextran solution.
Acetyl Tetrapeptide-2 References
SpecialChem, Website, Accessed March 2025
UL Prospector, Website, Accessed March 2025
ScienceDirect, Website, Accessed March 2025
Modern Health Science, March 2025, pages 69-78
Applied Sciences, December 2024, pages 1-6
Journal of Cosmetic Dermatology, January 2023, pages 245-254
Journal of the European Academy of Dermatology and Venereology, November 2021, pages 12-20
Aesthetic Surgery Journal Open Forum, August 2021, pages 1-8
International Journal of Peptide Research and Therapeutics, November 2017, pages 577-587